Amino Acid Changes in Hemagglutinin Contribute to the Replication of Oseltamivir-Resistant H1N1 Influenza Viruses

Oseltamivir-resistant H1N1 influenza viruses emerged in 2007 to 2008 and have subsequently circulated widely. However, prior to 2007 to 2008, viruses possessing the neuraminidase (NA) H274Y mutation, which confers oseltamivir resistance, generally had low growth capability. NA mutations that compens...

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Autors principals: Ginting, Teridah Ernala, Shinya, Kyoko, Kyan, Yukihiro, Makino, Akiko, Matsumoto, Naomi, Kaneda, Satoko, Kawaoka, Yoshihiro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255889/
https://ncbi.nlm.nih.gov/pubmed/22013054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06085-11
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