Amino Acid Changes in Hemagglutinin Contribute to the Replication of Oseltamivir-Resistant H1N1 Influenza Viruses

Oseltamivir-resistant H1N1 influenza viruses emerged in 2007 to 2008 and have subsequently circulated widely. However, prior to 2007 to 2008, viruses possessing the neuraminidase (NA) H274Y mutation, which confers oseltamivir resistance, generally had low growth capability. NA mutations that compens...

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Detalhes bibliográficos
Main Authors: Ginting, Teridah Ernala, Shinya, Kyoko, Kyan, Yukihiro, Makino, Akiko, Matsumoto, Naomi, Kaneda, Satoko, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255889/
https://ncbi.nlm.nih.gov/pubmed/22013054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06085-11
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