Characterization of a Neuraminidase-Deficient Influenza A Virus as a Potential Gene Delivery Vector and a Live Vaccine

We recently identified a packaging signal in the neuraminidase (NA) viral RNA (vRNA) segment of an influenza A virus, allowing us to produce a mutant virus [GFP(NA)-Flu] that lacks most of the NA open reading frame but contains instead the gene encoding green fluorescent protein (GFP). To exploit th...

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Detalhes bibliográficos
Main Authors: Shinya, Kyoko, Fujii, Yutaka, Ito, Hiroshi, Ito, Toshihiro, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC353727/
https://ncbi.nlm.nih.gov/pubmed/14990727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.3083-3088.2004
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