HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control

The genetic polymorphism that has the greatest impact on immune control of human immunodeficiency virus (HIV) infection is expression of HLA-B*57. Understanding of the mechanism for this strong effect remains incomplete. HLA-B*57 alleles and the closely related HLA-B*5801 are often grouped together...

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Main Authors: Kloverpris, Henrik N., Stryhn, Anette, Harndahl, Mikkel, van der Stok, Mary, Payne, Rebecca P., Matthews, Philippa C., Chen, Fabian, Riddell, Lynn, Walker, Bruce D., Ndung'u, Thumbi, Buus, Søren, Goulder, Philip
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255844/
https://ncbi.nlm.nih.gov/pubmed/22090105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06150-11
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