Structural Map of a MicroRNA-122:Hepatitis C Virus Complex

MicroRNA-122 (miR-122) enhances hepatitis C virus (HCV) fitness via targeting two sites in the 5′-untranslated region (UTR) of HCV. We used selective 2′-hydroxyl acylation analyzed by primer extension to resolve the HCV 5′-UTR's RNA secondary structure in the presence of miR-122. Nearly all nuc...

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Detalhes bibliográficos
Main Authors: Pang, Phillip S., Pham, Edward A., Elazar, Menashe, Patel, Shripa G., Eckart, Michael R., Glenn, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255806/
https://ncbi.nlm.nih.gov/pubmed/22072754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06367-11
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