Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

G protein-coupled receptors form hetero-dimers and higher order hetero-oligomers, yet the significance of receptor heteromerization in cellular and behavioral responses is poorly understood. Atypical antipsychotic drugs, such as clozapine and risperidone all have in common a high affinity for the se...

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Detalhes bibliográficos
Main Authors: Fribourg, Miguel, Moreno, José L., Holloway, Terrell, Provasi, Davide, Baki, Lia, Mahajan, Rahul, Park, Gyu, Adney, Scott K., Hatcher, Candice, Eltit, José M., Ruta, Jeffrey D., Albizu, Laura, Li, Zheng, Umali, Adrienne, Shim, Jihyun, Fabiato, Alexandre, MacKerell, Alexander D., Brezina, Vladimir, Sealfon, Stuart C., Filizola, Marta, González-Maeso, Javier, Logothetis, Diomedes E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255795/
https://ncbi.nlm.nih.gov/pubmed/22118459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.055
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