Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

G protein-coupled receptors form hetero-dimers and higher order hetero-oligomers, yet the significance of receptor heteromerization in cellular and behavioral responses is poorly understood. Atypical antipsychotic drugs, such as clozapine and risperidone all have in common a high affinity for the se...

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主要な著者: Fribourg, Miguel, Moreno, José L., Holloway, Terrell, Provasi, Davide, Baki, Lia, Mahajan, Rahul, Park, Gyu, Adney, Scott K., Hatcher, Candice, Eltit, José M., Ruta, Jeffrey D., Albizu, Laura, Li, Zheng, Umali, Adrienne, Shim, Jihyun, Fabiato, Alexandre, MacKerell, Alexander D., Brezina, Vladimir, Sealfon, Stuart C., Filizola, Marta, González-Maeso, Javier, Logothetis, Diomedes E.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255795/
https://ncbi.nlm.nih.gov/pubmed/22118459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.055
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