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Ku Regulates Signaling to DNA Damage Response Pathways through the Ku70 von Willebrand A Domain
The Ku heterodimer (Ku70/Ku80) is a main component of the nonhomologous end-joining (NHEJ) pathway that repairs DNA double-strand breaks (DSBs). Ku binds the broken DNA end and recruits other proteins to facilitate the processing and ligation of the broken end. While Ku interacts with many proteins...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255697/ https://ncbi.nlm.nih.gov/pubmed/22037767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05661-11 |
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