Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response

The Ku heterodimer (Ku70/Ku80) is the central DNA binding component of the classical non-homologous end joining (NHEJ) pathway that repairs DNA double-stranded breaks (DSBs), serving as the scaffold for the formation of the NHEJ complex. Here we show that Ku70 is phosphorylated on Serine 155 in resp...

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Udgivet i:Sci Rep
Main Authors: Fell, Victoria L., Walden, Elizabeth A., Hoffer, Sarah M., Rogers, Stephanie R., Aitken, Amelia S., Salemi, Louisa M., Schild-Poulter, Caroline
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111114/
https://ncbi.nlm.nih.gov/pubmed/27849008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37194
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