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Ku Regulates Signaling to DNA Damage Response Pathways through the Ku70 von Willebrand A Domain

The Ku heterodimer (Ku70/Ku80) is a main component of the nonhomologous end-joining (NHEJ) pathway that repairs DNA double-strand breaks (DSBs). Ku binds the broken DNA end and recruits other proteins to facilitate the processing and ligation of the broken end. While Ku interacts with many proteins...

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Autori principali: Fell, Victoria L., Schild-Poulter, Caroline
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255697/
https://ncbi.nlm.nih.gov/pubmed/22037767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05661-11
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