FLT3-regulated antigens as targets for leukemia-reactive cytotoxic T lymphocytes

The FMS-like tyrosine kinase 3 (FLT3) is highly expressed in acute myeloid leukemia (AML). Internal tandem duplications (ITD) of the juxtamembrane domain lead to the constitutive activation of the FLT3 kinase inducing the activation of multiple genes, which may result in the expression of leukemia-a...

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Autors principals: Brackertz, B, Conrad, H, Daniel, J, Kast, B, Krönig, H, Busch, D H, Adamski, J, Peschel, C, Bernhard, H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255276/
https://ncbi.nlm.nih.gov/pubmed/22829124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.12
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