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Targeting FLT3 for treatment of leukemia
FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is frequently overexpressed in acute leukemias and is frequently mutated in acute myeloid leukemia (AML). FLT3 internal tandem duplication (ITD) mutations in AML portend poor...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597087/ https://ncbi.nlm.nih.gov/pubmed/18760705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminhematol.2008.07.007 |
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