Inhibition of Rac controls NPM–ALK-dependent lymphoma development and dissemination

Nucleophosmin-anaplastic lymphoma kinase (NPM–ALK) is a tyrosine kinase oncogene responsible for the pathogenesis of the majority of human ALK-positive lymphomas. We recently reported that it activated the Rac1 GTPase in anaplastic large-cell lymphoma (ALCL), leading to Rac-dependent formation of ac...

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Autors principals: Colomba, A, Giuriato, S, Dejean, E, Thornber, K, Delsol, G, Tronchère, H, Meggetto, F, Payrastre, B, Gaits-Iacovoni, F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255265/
https://ncbi.nlm.nih.gov/pubmed/22829165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.19
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