Inhibition of Rac controls NPM–ALK-dependent lymphoma development and dissemination

Nucleophosmin-anaplastic lymphoma kinase (NPM–ALK) is a tyrosine kinase oncogene responsible for the pathogenesis of the majority of human ALK-positive lymphomas. We recently reported that it activated the Rac1 GTPase in anaplastic large-cell lymphoma (ALCL), leading to Rac-dependent formation of ac...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Colomba, A, Giuriato, S, Dejean, E, Thornber, K, Delsol, G, Tronchère, H, Meggetto, F, Payrastre, B, Gaits-Iacovoni, F
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2011
Предметы:
Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255265/
https://ncbi.nlm.nih.gov/pubmed/22829165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.19
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы