Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells

Malignant cells are known to have increased glucose uptake and accelerated glucose metabolism. Using liquid chromatography and mass spectrometry, we found that treatment of acute lymphoblastic leukemia (ALL) cells with the glucocorticoid (GC) dexamethasone (Dex) resulted in profound inhibition of gl...

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Detalhes bibliográficos
Main Authors: Buentke, E, Nordström, A, Lin, H, Björklund, A-C, Laane, E, Harada, M, Lu, L, Tegnebratt, T, Stone-Elander, S, Heyman, M, Söderhäll, S, Porwit, A, Östenson, C-G, Shoshan, M, Tamm, K Pokrovskaja, Grandér, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255251/
https://ncbi.nlm.nih.gov/pubmed/22829187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.27
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