Φορτώνει......
Doxorubicin Requires the Sequential Activation of Caspase-2, Protein Kinase Cδ, and c-Jun NH(2)-terminal Kinase to Induce Apoptosis
Here, we identified caspase-2, protein kinase C (PKC)δ, and c-Jun NH(2)-terminal kinase (JNK) as key components of the doxorubicin-induced apoptotic cascade. Using cells stably transfected with an antisense construct for caspase-2 (AS2) as well as a chemical caspase-2 inhibitor, we demonstrate that...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The American Society for Cell Biology
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1182319/ https://ncbi.nlm.nih.gov/pubmed/15917298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-10-0862 |
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