Doxorubicin Requires the Sequential Activation of Caspase-2, Protein Kinase Cδ, and c-Jun NH(2)-terminal Kinase to Induce Apoptosis

Here, we identified caspase-2, protein kinase C (PKC)δ, and c-Jun NH(2)-terminal kinase (JNK) as key components of the doxorubicin-induced apoptotic cascade. Using cells stably transfected with an antisense construct for caspase-2 (AS2) as well as a chemical caspase-2 inhibitor, we demonstrate that...

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Main Authors: Panaretakis, Theocharis, Laane, Edward, Pokrovskaja, Katja, Björklund, Ann-Charlotte, Moustakas, Aristidis, Zhivotovsky, Boris, Heyman, Mats, Shoshan, Maria C., Grandér, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2005
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182319/
https://ncbi.nlm.nih.gov/pubmed/15917298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-10-0862
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