Proteolytic processing of Alzheimer’s β-amyloid precursor protein

β–amyloid precursor protein (APP) is a critical factor in the pathogenesis of Alzheimer’s disease (AD). APP undergoes posttranslational proteolysis/processing to generate the hydrophobic β-amyloid (Aβ) peptides. Deposition of Aβ in the brain, forming oligomeric Aβ and plaques, is identified as one o...

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Bibliographic Details
Main Authors: Zhang, Han, Ma, Qilin, Zhang, Yun-wu, Xu, Huaxi
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254787/
https://ncbi.nlm.nih.gov/pubmed/22122372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07519.x
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