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γ-SECRETASE INHIBITORS AND MODULATORS FOR ALZHEIMER’S DISEASE
γ-Secretase is a membrane embedded aspartyl protease complex with presenilin as the catalytic component. Along with β-secretase, this enzyme produces the amyloid β-protein (Aβ) of Alzheimer’s disease (AD) from the amyloid β-protein precursor (APP). Because of its key role in the pathogenesis of AD,...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3254709/ https://ncbi.nlm.nih.gov/pubmed/22122056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07501.x |
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