PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo

It is reported that PTP1B limits cytokine signaling in vitro. However, PTP1B’s function during inflammation in vivo is not known. In this report, we determined whether PTP1B deficiency affects allergic inflammation in vivo. Briefly, lungs of OVA-challenged PTP1B−/− mice had elevated numbers of eosin...

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Hlavní autoři: Berdnikovs, Sergejs, Pavlov, Vladimir I., Abdala-Valencia, Hiam, McCary, Christine A., Klumpp, David J., Tremblay, Michel L., Cook-Mills, Joan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253258/
https://ncbi.nlm.nih.gov/pubmed/22156494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004108
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