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Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II
G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR kinases, and arrestins. Constitutively active mutants are ubiquitously found among GPCRs and increase the...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252945/ https://ncbi.nlm.nih.gov/pubmed/22198838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114089108 |
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