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Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR kinases, and arrestins. Constitutively active mutants are ubiquitously found among GPCRs and increase the...

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Библиографические подробности
Главные авторы: Deupi, Xavier, Edwards, Patricia, Singhal, Ankita, Nickle, Benjamin, Oprian, Daniel, Schertler, Gebhard, Standfuss, Jörg
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252945/
https://ncbi.nlm.nih.gov/pubmed/22198838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114089108
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