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Crystal Structure of a Thermally Stable Rhodopsin Mutant

We determined the structure of the rhodopsin mutant N2C/D282C expressed in mammalian cells; the first structure of a recombinantly produced G protein-coupled receptor (GPCR). The mutant was designed to form a disulfide bond between the N-terminus and loop E3 which allows handling of opsin in deterge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Standfuss, Jörg, Xie, Guifu, Edwards, Patricia C., Burghammer, Manfred, Oprian, Daniel D., Schertler, Gebhard F. X.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258155/
https://ncbi.nlm.nih.gov/pubmed/17825322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.03.007
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