Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and progenitor cells; however, direct cellular targets and specific functions of Notch signals had not been identified. We show here in mice that Notch directly targets the crypt base columnar (CBC) cell to...

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Bibliografiska uppgifter
Huvudupphovsmän: VanDussen, Kelli L., Carulli, Alexis J., Keeley, Theresa M., Patel, Sanjeevkumar R., Puthoff, Brent J., Magness, Scott T., Tran, Ivy T., Maillard, Ivan, Siebel, Christian, Kolterud, Åsa, Grosse, Ann S., Gumucio, Deborah L., Ernst, Stephen A., Tsai, Yu-Hwai, Dempsey, Peter J., Samuelson, Linda C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Company of Biologists 2012
Ämnen:
Development and Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252352/
https://ncbi.nlm.nih.gov/pubmed/22190634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.070763
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