Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition

Intestinal crypts have great capacity for repair and regeneration after intestinal stem cell (ISC) injury. Here, we define the cellular remodeling process resulting from ISC niche interruption by transient Notch pathway inhibition in adult mice. Although ISCs were retained, lineage tracing demonstra...

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Опубликовано в: :Stem Cell Reports
Главные авторы: Bohin, Natacha, Keeley, Theresa M., Carulli, Alexis J., Walker, Emily M., Carlson, Elizabeth A., Gao, Jie, Aifantis, Iannis, Siebel, Christian W., Rajala, Michael W., Myers, Martin G., Jones, Jennifer C., Brindley, Constance D., Dempsey, Peter J., Samuelson, Linda C.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363878/
https://ncbi.nlm.nih.gov/pubmed/32531190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.05.010
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