Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition

Intestinal crypts have great capacity for repair and regeneration after intestinal stem cell (ISC) injury. Here, we define the cellular remodeling process resulting from ISC niche interruption by transient Notch pathway inhibition in adult mice. Although ISCs were retained, lineage tracing demonstra...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Bohin, Natacha, Keeley, Theresa M., Carulli, Alexis J., Walker, Emily M., Carlson, Elizabeth A., Gao, Jie, Aifantis, Iannis, Siebel, Christian W., Rajala, Michael W., Myers, Martin G., Jones, Jennifer C., Brindley, Constance D., Dempsey, Peter J., Samuelson, Linda C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363878/
https://ncbi.nlm.nih.gov/pubmed/32531190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.05.010
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