Notch signaling regulates gastric antral LGR5 stem cell function

The major signaling pathways regulating gastric stem cells are unknown. Here we report that Notch signaling is essential for homeostasis of LGR5(+) antral stem cells. Pathway inhibition reduced proliferation of gastric stem and progenitor cells, while activation increased proliferation. Notch dysreg...

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Pubblicato in:EMBO J
Autori principali: Demitrack, Elise S, Gifford, Gail B, Keeley, Theresa M, Carulli, Alexis J, VanDussen, Kelli L, Thomas, Dafydd, Giordano, Thomas J, Liu, Zhenyi, Kopan, Raphael, Samuelson, Linda C
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609184/
https://ncbi.nlm.nih.gov/pubmed/26271103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490583
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