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Notch signaling regulates gastric antral LGR5 stem cell function
The major signaling pathways regulating gastric stem cells are unknown. Here we report that Notch signaling is essential for homeostasis of LGR5(+) antral stem cells. Pathway inhibition reduced proliferation of gastric stem and progenitor cells, while activation increased proliferation. Notch dysreg...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609184/ https://ncbi.nlm.nih.gov/pubmed/26271103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490583 |
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