Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis

OBJECTIVE: We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. DESIGN: Mice were treated with the pan-Notch inhibitor dibenzazepine (DBZ) or inhibitory antibodies targeting Notch1 and/or Notch2...

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Pubblicato in:Gut
Autori principali: Gifford, Gail B, Demitrack, Elise S, Keeley, Theresa M, Tam, Andrew, La Cunza, Nilsa, Dedhia, Priya H, Spence, Jason R, Simeone, Diane M, Saotome, Ichiko, Louvi, Angeliki, Siebel, Christian W, Samuelson, Linda C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009003/
https://ncbi.nlm.nih.gov/pubmed/26933171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310811
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