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Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin
BACKGROUND: Botulinum neurotoxin A (BoNT/A), mainly represented by subtype A1, is the most toxic substance known. It causes naturally-occurring food poisoning, and is among the biological agents at the highest risk of being weaponized. Several antibodies neutralizing BoNT/A by targeting its heavy ch...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2011
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252318/ https://ncbi.nlm.nih.gov/pubmed/22111995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-11-113 |
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