Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A(1) and A(2) by targeting their heavy chain

BACKGROUND: Botulism is a naturally occurring disease, mainly caused by the ingestion of food contaminated by the botulinum neurotoxins (BoNTs). Botulinum neurotoxins are the most lethal. They are classified among the six major biological warfare agents by the Centers for Disease Control. BoNTs act...

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Udgivet i:BMC Biotechnol
Main Authors: Avril, Arnaud, Miethe, Sebastian, Popoff, Michel R., Mazuet, Christelle, Chahboun, Siham, Rasetti-Escargueil, Christine, Sesardic, Dorothea, Thullier, Philippe, Hust, Michael, Pelat, Thibaut
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574468/
https://ncbi.nlm.nih.gov/pubmed/26382731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0206-0
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