Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults

BACKGROUND: DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques. METHODOLOGY/PRINCIPAL FINDINGS: We performed two first in human...

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Detalhes bibliográficos
Main Authors: Kalams, Spyros A., Parker, Scott, Jin, Xia, Elizaga, Marnie, Metch, Barbara, Wang, Maggie, Hural, John, Lubeck, Michael, Eldridge, John, Cardinali, Massimo, Blattner, William A., Sobieszczyk, Magda, Suriyanon, Vinai, Kalichman, Artur, Weiner, David B., Baden, Lindsey R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252307/
https://ncbi.nlm.nih.gov/pubmed/22242162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029231
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