Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults

BACKGROUND: DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques. METHODOLOGY/PRINCIPAL FINDINGS: We performed two first in human...

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Bibliografiske detaljer
Main Authors: Kalams, Spyros A., Parker, Scott, Jin, Xia, Elizaga, Marnie, Metch, Barbara, Wang, Maggie, Hural, John, Lubeck, Michael, Eldridge, John, Cardinali, Massimo, Blattner, William A., Sobieszczyk, Magda, Suriyanon, Vinai, Kalichman, Artur, Weiner, David B., Baden, Lindsey R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252307/
https://ncbi.nlm.nih.gov/pubmed/22242162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029231
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