Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

Background. DNA vaccines have been very poorly immunogenic in humans but have been an effective priming modality in prime-boost regimens. Methods to increase the immunogenicity of DNA vaccines are needed. Methods. HIV Vaccine Trials Network (HVTN) studies 070 and 080 were multicenter, randomized, cl...

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Hauptverfasser: Kalams, Spyros A., Parker, Scott D., Elizaga, Marnie, Metch, Barbara, Edupuganti, Srilatha, Hural, John, De Rosa, Stephen, Carter, Donald K., Rybczyk, Kyle, Frank, Ian, Fuchs, Jonathan, Koblin, Beryl, Kim, Denny H., Joseph, Patrice, Keefer, Michael C., Baden, Lindsey R., Eldridge, John, Boyer, Jean, Sherwat, Adam, Cardinali, Massimo, Allen, Mary, Pensiero, Michael, Butler, Chris, Khan, Amir S., Yan, Jian, Sardesai, Niranjan Y., Kublin, James G., Weiner, David B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
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Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733506/
https://ncbi.nlm.nih.gov/pubmed/23840043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit236
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