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How Can HIV-Type-1-Env Immunogenicity Be Improved to Facilitate Antibody-Based Vaccine Development?

No vaccine candidate has induced antibodies (Abs) that efficiently neutralize multiple primary isolates of HIV-1. Preexisting high titers of neutralizing antibodies (NAbs) are essential, because the virus establishes infection before anamnestic responses could take effect. HIV-1 infection elicits Ab...

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Detalhes bibliográficos
Main Authors: Klasse, Per Johan, Sanders, Rogier W., Cerutti, Andrea, Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251839/
https://ncbi.nlm.nih.gov/pubmed/21495876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2011.0053
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