TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome

PURPOSE: Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis. Intestinal macrophages could recognize invading bacterial DNA via TLR9 receptors a...

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Bibliographic Details
Main Authors: Saha, Subhrajit, Bhanja, Payel, Liu, Laibin, Alfieri, Alan A., Yu, Dong, Kandimalla, Ekambar R., Agrawal, Sudhir, Guha, Chandan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251576/
https://ncbi.nlm.nih.gov/pubmed/22238604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029357
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