Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase

Long interspersed element-1 (LINE-1 or L1) retrotransposons encode two proteins (ORF1p and ORF2p) that contain activities required for conventional retrotransposition by a mechanism termed target-site primed reverse transcription. Previous experiments in XRCC4 or DNA protein kinase catalytic subunit...

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Bibliographic Details
Main Authors: Kopera, Huira C., Moldovan, John B., Morrish, Tammy A., Garcia-Perez, Jose Luis, Moran, John V.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Telomerase and Retrotransposons: Reverse Transcriptases That Shaped Genomes Special Feature Sackler Colloquium
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251045/
https://ncbi.nlm.nih.gov/pubmed/21940498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100275108
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