Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro

BACKGROUND: Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly use...

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Detalhes bibliográficos
Main Authors: Brand, Yves, Setz, Cristian, Levano, Soledad, Listyo, Alwin, Chavez, Eduardo, Pak, Kwang, Sung, Michael, Radojevic, Vesna, Ryan, Allen F, Bodmer, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250952/
https://ncbi.nlm.nih.gov/pubmed/22082490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-12-114
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