Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro

Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR) by blocking the mTOR complex 1 (mTORC1). mTOR is an atypical serine/threonine protein kinase, which controls cell growth, cell proliferation, and cell metabolism. However,...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biomed Res Int
Main Authors: Leitmeyer, Katharina, Glutz, Andrea, Radojevic, Vesna, Setz, Cristian, Huerzeler, Nathan, Bumann, Helen, Bodmer, Daniel, Brand, Yves
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395993/
https://ncbi.nlm.nih.gov/pubmed/25918725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/925890
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