Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro

Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR) by blocking the mTOR complex 1 (mTORC1). mTOR is an atypical serine/threonine protein kinase, which controls cell growth, cell proliferation, and cell metabolism. However,...

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Publicat a:Biomed Res Int
Autors principals: Leitmeyer, Katharina, Glutz, Andrea, Radojevic, Vesna, Setz, Cristian, Huerzeler, Nathan, Bumann, Helen, Bodmer, Daniel, Brand, Yves
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395993/
https://ncbi.nlm.nih.gov/pubmed/25918725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/925890
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