Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro

Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR) by blocking the mTOR complex 1 (mTORC1). mTOR is an atypical serine/threonine protein kinase, which controls cell growth, cell proliferation, and cell metabolism. However,...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Leitmeyer, Katharina, Glutz, Andrea, Radojevic, Vesna, Setz, Cristian, Huerzeler, Nathan, Bumann, Helen, Bodmer, Daniel, Brand, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395993/
https://ncbi.nlm.nih.gov/pubmed/25918725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/925890
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