Impaired CK1 Delta Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo

Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular kinases, among them members of the CK1 family, play an important role in modulating the transforming activity of SV40, including the transformin...

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Detalhes bibliográficos
Main Authors: Hirner, Heidrun, Günes, Cagatay, Bischof, Joachim, Wolff, Sonja, Grothey, Arnhild, Kühl, Marion, Oswald, Franz, Wegwitz, Florian, Bösl, Michael R., Trauzold, Anna, Henne-Bruns, Doris, Peifer, Christian, Leithäuser, Frank, Deppert, Wolfgang, Knippschild, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250488/
https://ncbi.nlm.nih.gov/pubmed/22235331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029709
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