Glucose-Induced O(2) Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

BACKGROUND: Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-dependent manner. METHODOLOGY/PRINCIPAL FINDINGS: Isol...

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Bibliographic Details
Main Authors: Bensellam, Mohammed, Duvillié, Bertrand, Rybachuk, Galyna, Laybutt, D. Ross, Magnan, Christophe, Guiot, Yves, Pouysségur, Jacques, Jonas, Jean-Christophe
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250482/
https://ncbi.nlm.nih.gov/pubmed/22235342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029807
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