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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in Ts65Dn mice, the most widely used model of Down syndrome (DS). Here we demonstrate a direct link between gene triplication and defects in neuron production during embryonic development. These neurogenesis defe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249618/ https://ncbi.nlm.nih.gov/pubmed/20639873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2600 |
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