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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in Ts65Dn mice, the most widely used model of Down syndrome (DS). Here we demonstrate a direct link between gene triplication and defects in neuron production during embryonic development. These neurogenesis defe...

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Bibliografiske detaljer
Main Authors: Chakrabarti, Lina, Best, Tyler K., Cramer, Nathan P., Carney, Rosalind S.E., Isaac, John T.R., Galdzicki, Zygmunt, Haydar, Tarik F.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249618/
https://ncbi.nlm.nih.gov/pubmed/20639873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2600
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