Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

Trisomy 21, or Down syndrome (DS), is the most common genetic cause of developmental delay and intellectual disability. To gain insight into the underlying molecular and cellular pathogenesis, we conducted a multi-region transcriptome analysis of DS and euploid control brains spanning from mid-fetal...

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Publicado en:Neuron
Autores principales: Olmos-Serrano, Jose Luis, Kang, Hyo Jung, Tyler, William A., Silbereis, John C., Cheng, Feng, Zhu, Ying, Pletikos, Mihovil, Jankovic-Rapan, Lucija, Cramer, Nathan P., Galdzicki, Zygmunt, Goodliffe, Joseph, Peters, Alan, Sethares, Claire, Delalle, Ivana, Golden, Jeffrey A., Haydar, Tarik F., Sestan, Nenad
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795969/
https://ncbi.nlm.nih.gov/pubmed/26924435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.01.042
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