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BCR-ABL1 kinase facilitates localization of acetylated histones 3 and 4 on DNA double-strand breaks
BCR-ABL1 kinase-positive leukemia cells accumulate high numbers of DNA double-strand breaks (DSBs) induced by the reactive oxygen species (ROS) or cytotoxic agents. To repair these lesions and prevent apoptosis BCR-ABL1 kinase stimulates the efficiency of DSB repair in leukemia cells. Histone acetyl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249465/ https://ncbi.nlm.nih.gov/pubmed/22036635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2011.10.007 |
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