Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

GPR55 is activated by l-α-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In this study, we investigated the GPR55 pharmacology of various cannabinoids, including analogues of the CB(1) receptor antagonist Rimonabant®, CB(2) receptor agonists, and Cannabis sativa constituents. To te...

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Hlavní autoři: Anavi-Goffer, Sharon, Baillie, Gemma, Irving, Andrew J., Gertsch, Jürg, Greig, Iain R., Pertwee, Roger G., Ross, Ruth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249141/
https://ncbi.nlm.nih.gov/pubmed/22027819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296020
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