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Increasing Rate of Cleavage at Boundary between Non-structural Proteins 4B and 5A Inhibits Replication of Hepatitis C Virus

In hepatitis C virus, non-structural proteins are cleaved from the viral polyprotein by viral encoded proteases. Although proteolytic processing goes to completion, the rate of cleavage differs between different boundaries, primarily due to the sequence at these positions. However, it is not known w...

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Autors principals: Herod, Morgan R., Jones, Daniel M., McLauchlan, John, McCormick, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249110/
https://ncbi.nlm.nih.gov/pubmed/22084249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311407
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