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Increasing Rate of Cleavage at Boundary between Non-structural Proteins 4B and 5A Inhibits Replication of Hepatitis C Virus

In hepatitis C virus, non-structural proteins are cleaved from the viral polyprotein by viral encoded proteases. Although proteolytic processing goes to completion, the rate of cleavage differs between different boundaries, primarily due to the sequence at these positions. However, it is not known w...

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Main Authors: Herod, Morgan R., Jones, Daniel M., McLauchlan, John, McCormick, Christopher J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249110/
https://ncbi.nlm.nih.gov/pubmed/22084249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311407
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