Anion Activation Site of Insulin-degrading Enzyme

Insulin-degrading enzyme (IDE) (insulysin) is a zinc metallopeptidase that metabolizes several bioactive peptides, including insulin and the amyloid β peptide. IDE is an unusual metallopeptidase in that it is allosterically activated by both small peptides and anions, such as ATP. Here, we report th...

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Bibliographic Details
Main Authors: Noinaj, Nicholas, Song, Eun Suk, Bhasin, Sonia, Alper, Benjamin J., Schmidt, Walter K., Hersh, Louis B., Rodgers, David W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249101/
https://ncbi.nlm.nih.gov/pubmed/22049080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264614
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