E1-E2 Interactions in Ubiquitin and Nedd8 Ligation Pathways

Initial rates of E1-catalyzed E2 transthiolation have been used as a reporter function to probe the mechanism of (125)I-ubiquitin transfer between activation and ligation half-reactions of ubiquitin conjugation. A functional survey of 11 representative human E2 paralogs reveals similar K(m) for bind...

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Autors principals: Tokgöz, Zeynep, Siepmann, Thomas J., Streich, Frederick, Kumar, Brajesh, Klein, Jennifer M., Haas, Arthur L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249083/
https://ncbi.nlm.nih.gov/pubmed/22069333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294975
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