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Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1
[Image: see text] Post-translational covalent modification by ubiquitin and ubiquitin-like proteins (UBLs) is a major eukaryotic mechanism for regulating protein function. In general, each UBL has its own E1 that serves as the entry point for a cascade. The E1 first binds the UBL and catalyzes adeny...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2008
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587436/ https://ncbi.nlm.nih.gov/pubmed/18652489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800604c |
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