Discovery, Design and Synthesis of Novel Potent and Selective Sphingosine-1-Phosphate 4 Receptor (S1P(4)-R) Agonists

High affinity and selective small molecule agonists of the S1P(4) receptor (S1P(4)-R) may have significant therapeutic utility in diverse disease areas including autoimmune diseases, viral infections and thrombocytopenia. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Re...

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Main Authors: Guerrero, Miguel, Urbano, Mariangela, Zhao, Jian, Crisp, Melissa, Chase, Peter, Hodder, Peter, Schaeffer, Marie-Therese, Brown, Steven, Rosen, Hugh, Roberts, Edward
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248976/
https://ncbi.nlm.nih.gov/pubmed/22119461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.096
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