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Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2
Histone deacetylases (HDACs) are major epigenetic modulators involved in a broad spectrum of human diseases including cancers. Administration of HDAC inhibitors (HDACis) leads to growth inhibition, differentiation, and apoptosis of cancer cells. Understanding the regulatory mechanism of HDACs is imp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248682/ https://ncbi.nlm.nih.gov/pubmed/22016339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.170605.111 |
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