Probing the SELEX Process with Next-Generation Sequencing

BACKGROUND: SELEX is an iterative process in which highly diverse synthetic nucleic acid libraries are selected over many rounds to finally identify aptamers with desired properties. However, little is understood as how binders are enriched during the selection course. Next-generation sequencing off...

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Detalhes bibliográficos
Main Authors: Schütze, Tatjana, Wilhelm, Barbara, Greiner, Nicole, Braun, Hannsjörg, Peter, Franziska, Mörl, Mario, Erdmann, Volker A., Lehrach, Hans, Konthur, Zoltán, Menger, Marcus, Arndt, Peter F., Glökler, Jörn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248438/
https://ncbi.nlm.nih.gov/pubmed/22242135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029604
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