Probing the SELEX Process with Next-Generation Sequencing

BACKGROUND: SELEX is an iterative process in which highly diverse synthetic nucleic acid libraries are selected over many rounds to finally identify aptamers with desired properties. However, little is understood as how binders are enriched during the selection course. Next-generation sequencing off...

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Hlavní autoři: Schütze, Tatjana, Wilhelm, Barbara, Greiner, Nicole, Braun, Hannsjörg, Peter, Franziska, Mörl, Mario, Erdmann, Volker A., Lehrach, Hans, Konthur, Zoltán, Menger, Marcus, Arndt, Peter F., Glökler, Jörn
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248438/
https://ncbi.nlm.nih.gov/pubmed/22242135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029604
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